Sibiriak S V
Antibiotiki. 1983 Jun;28(6):449-52.
The effect of prodigiozan and methyluracil on the development of adjuvant arthritis was studied on 120 noninbred albino rats. When prodigiozan was used in a dose of 50 micrograms per 100 g of the body weight once every 4 days beginning from the 1st to the 12th day after the injection of the complete Freund adjuvant, it inhibited the development of arthritis and lowered the level of the "inflammatory units" in the plasma. When prodigiozan was used from the 9th to the 23rd day after the adjuvant injection, it accelerated the development of arthritis and made more pronounced the clinical signs of the disease. The use of methyluracil in a dose of 200 mg/kg daily from the 1st to the 12th day after the adjuvant injection had no effect on the arthritis development, while its use from the 9th to the 23rd day after the adjuvant injection had a pronounced antiinflammatory effect. The data suggest that combinations of prodigiozan and methyluracil with antiinflammatory and immunodepressant agents might be used in the treatment of autoimmune diseases.
在120只非近交系白化大鼠身上研究了灵菌红素和甲基尿嘧啶对佐剂性关节炎发展的影响。从注射完全弗氏佐剂后的第1天至第12天，当以每100克体重50微克的剂量每4天一次使用灵菌红素时，它抑制了关节炎的发展并降低了血浆中“炎症单位”的水平。当在佐剂注射后的第9天至第23天使用灵菌红素时，它加速了关节炎的发展并使疾病的临床症状更加明显。从佐剂注射后的第1天至第12天，每天以200毫克/千克的剂量使用甲基尿嘧啶对关节炎的发展没有影响，而在佐剂注射后的第9天至第23天使用时则具有明显的抗炎作用。数据表明，灵菌红素和甲基尿嘧啶与抗炎和免疫抑制剂的组合可能用于治疗自身免疫性疾病。
