Sawada M, Okudaira Y, Matsui Y, Miyoshi Y, Takayama K, Shimizu Y, Miura S
Gan To Kagaku Ryoho. 1983 Aug;10(8):1823-30.
Immunosuppressive acidic protein (IAP) was determined in sera of patients with gynecologic tumors and pregnant women using the single radial immunodiffusion method. The normal limit of IAP of 490 micrograms/ml was derived from the mean value +2S.D. of IAP in 150 healthy females. Among 141 patients with gynecologic cancers, serum IAP was elevated in 87 patients (62%). Among 190 patients with benign tumors (98 uterine myoma, 92 benign ovarian tumors) serum IAP was elevated in 14 patients (7%). The level of IAP in sera of 201 pregnant women was almost identical with that of the healthy females. Elevated levels of IAP were recognized in 43% of 77 patients with cervical cancer, in 55% of 11 endometrial cancer patients and in 91% of 53 ovarian cancer patients. IAP determination was most effective in ovarian cancer for the early detection of cancer. IAP determinations may provide a useful method for the detection of recurrence of cervical cancer.
采用单向辐射免疫扩散法测定了妇科肿瘤患者和孕妇血清中的免疫抑制酸性蛋白（IAP）。IAP的正常上限490微克/毫升是根据150名健康女性IAP的平均值加2个标准差得出的。在141例妇科癌症患者中，87例（62%）血清IAP升高。在190例良性肿瘤患者（98例子宫肌瘤、92例卵巢良性肿瘤）中，14例（7%）血清IAP升高。201例孕妇血清IAP水平与健康女性几乎相同。在77例宫颈癌患者中，43%的患者IAP水平升高；在11例子宫内膜癌患者中，55%的患者IAP水平升高；在53例卵巢癌患者中，91%的患者IAP水平升高。IAP测定对卵巢癌的早期检测最为有效。IAP测定可能为宫颈癌复发的检测提供一种有用的方法。
