Sawada M, Okudaira Y, Matsui Y, Shimizu Y
Cancer. 1984 Aug 15;54(4):652-6. doi: 10.1002/1097-0142(1984)54:4<652::aid-cncr2820540411>3.0.co;2-c.
Immunosuppressive acidic protein (IAP) was determined in sera of patients with gynecologic tumors using the single radial immunodiffusion method. The normal limit of IAP of 490 micrograms/ml was derived from the mean value + 2 SD of IAP in 150 healthy females. Among 141 patients with gynecologic cancers, serum IAP was elevated in 87 patients (62%). Among 190 patients with benign tumors (98 uterine myoma, 92 benign ovarian tumors) serum IAP was elevated in 14 patients (7%). Elevated levels of IAP were recognized in 43% of 77 patients with cervical cancer, in 55% of 11 endometrial cancer patients, and in 91% of 53 ovarian cancer patients. The frequency of elevated levels showed a tendency to increase with advancing stage of disease. In ovarian cancer elevation of IAP was observed even in early stages. All of 13 patients with recurrent cervical cancer had elevated IAP while only 6 of 35 (17%) previously treated patients without evidence of recurrence had elevated IAP. Immunosuppressive acidic protein determinations may be useful in monitoring the recurrence of cervical cancer. The measurement of serum IAP as a marker for gynecologic cancer is recommended as an addition to diagnostic procedures.
采用单向免疫扩散法测定妇科肿瘤患者血清中的免疫抑制酸性蛋白（IAP）。IAP的正常上限490微克/毫升来自150名健康女性IAP的平均值加2倍标准差。在141例妇科癌症患者中，87例（62%）血清IAP升高。在190例良性肿瘤患者（98例子宫肌瘤、92例卵巢良性肿瘤）中，14例（7%）血清IAP升高。77例宫颈癌患者中有43%、11例子宫内膜癌患者中有55%、53例卵巢癌患者中有91%的IAP水平升高。IAP水平升高的频率有随疾病分期进展而增加的趋势。在卵巢癌中，即使在早期也观察到IAP升高。13例复发性宫颈癌患者的IAP均升高，而35例既往接受过治疗且无复发证据的患者中只有6例（17%）IAP升高。免疫抑制酸性蛋白测定可能有助于监测宫颈癌的复发。建议测定血清IAP作为妇科癌症的标志物，作为诊断程序的补充。
