Debeljuk L, Díaz M D, Maines V M, Seilicovich A
Arch Androl. 1983 Jun;10(3):239-43. doi: 10.3109/01485018308987572.
The effect of chronic treatment with a gamma-aminobutyric acid (GABA)-mimetic compound, progabide, and an inhibitor of GABA-transaminase, gamma-acetylenic GABA (GAG), was tested in prepubertal male rats. The effect of gamma-butyrolactone (GBL), given orally, was also tested. The rats treated with progabide did not show any difference in body, testicular, or seminal vesicle weights or serum prolactin levels, as compared with control rats. Treatment with GAG, at both dose levels used, did not significantly affect body weight. Testicular weight was significantly lower in the group of rats treated with the low dosage of GAG (5 mg/kg), and serum prolactin was significantly lower in the rats treated with the high dosage of GAG (20 mg/kg) as compared with control rats. In the first experiment performed with GBL, the rats given this compound had significantly lower body and testicular weights as compared with control rats. In the second experiment, GBL-treated rats had body weights similar to those of control rats, but testicular weights were significantly decreased. Prolonged treatment with GABA mimetics may affect the hypothalamic-pituitary-testicular axis.
在青春期前雄性大鼠中测试了用γ-氨基丁酸（GABA）模拟化合物普罗加比和GABA转氨酶抑制剂γ-乙炔基GABA（GAG）进行长期治疗的效果。还测试了口服γ-丁内酯（GBL）的效果。与对照大鼠相比，用普罗加比治疗的大鼠在体重、睾丸或精囊重量或血清催乳素水平上没有显示出任何差异。在使用的两个剂量水平下，用GAG治疗均未显著影响体重。与对照大鼠相比，用低剂量GAG（5mg/kg）治疗的大鼠组睾丸重量显著降低，用高剂量GAG（20mg/kg）治疗的大鼠血清催乳素显著降低。在首次用GBL进行的实验中，给予该化合物的大鼠与对照大鼠相比，体重和睾丸重量显著降低。在第二次实验中，用GBL治疗的大鼠体重与对照大鼠相似，但睾丸重量显著降低。用GABA模拟物进行长期治疗可能会影响下丘脑-垂体-睾丸轴。
