Talas A, Wellhöner H H
Arch Toxicol. 1983 May;53(1):9-16. doi: 10.1007/BF01459997.
The dose-dependency of Tl+ kinetics was studied in rabbits by intravenous injection first of a 201Tl+ tracer dose and 2 weeks later of a 5.5 mumol/kg dose. For either dose level, an open three compartment model was appropriate to describe the course of the plasma concentration curve. With the dosage increase a slight to moderate decrease in the distribution volumes (11.2 l/kg versus 9.7 l/kg) and in the plasma clearance (13 ml/min versus 9 ml/min) was found. Two days after injection of both the high and the low dose considerable amounts of Tl+ were found in the intestinal contents and only small amounts were found in the bile.
通过先静脉注射201Tl+示踪剂量，两周后再静脉注射5.5 μmol/kg剂量，在兔子身上研究了Tl+动力学的剂量依赖性。对于任一剂量水平，开放三室模型都适合描述血浆浓度曲线的过程。随着剂量增加，分布容积（11.2 l/kg对9.7 l/kg）和血浆清除率（13 ml/min对9 ml/min）出现轻微至中度下降。在注射高剂量和低剂量后两天，在肠内容物中发现了大量的Tl+，而在胆汁中仅发现少量。
