Sabbioni E, Di Nucci A, Edel J, Gregotti C, Marafante E, Manzo L
Arch Toxicol Suppl. 1984;7:446-50. doi: 10.1007/978-3-642-69132-4_88.
The gastrointestinal transport of 201Tl-labelled monovalent thallium has been studied in normal and rats with cannulated bile ducts using an in vivo ligated loop technique. A marked difference in the Tl absorptive capacity among the various sections of the gut was observed. 201Tl was taken up more quickly from the colon than from any other segment and the uptake from the ileum and jejunum was higher than from the stomach. In addition, considerable amounts of the intravenously administered thallium were excreted into the intestinal lumen. The biliary excretion was very low compared with the direct transfer of 201Tl across the gastrointestinal wall that occurred against a tissue-to-plasma concentration gradient. In the rat, the large intestine seems to be the major area for the enteral reabsorption and recycling of thallium (I) ions.
利用体内结扎肠袢技术，对正常大鼠和胆管插管大鼠的201Tl标记一价铊的胃肠道转运进行了研究。观察到肠道各段铊的吸收能力存在显著差异。201Tl从结肠的吸收比从其他任何节段都更快，回肠和空肠的吸收高于胃。此外，静脉注射的大量铊被排泄到肠腔内。与201Tl逆组织-血浆浓度梯度直接穿过胃肠道壁相比，胆汁排泄非常低。在大鼠中，大肠似乎是铊（I）离子肠内重吸收和再循环的主要部位。
