Ichimura K, Jackson R T
Arch Otolaryngol. 1983 Sep;109(9):593-7. doi: 10.1001/archotol.1983.00800230029007.
A canine in vitro nasal blood vessel preparation was tested to determine the effects of calcium (Ca) on smooth-muscle contraction. The contractions induced by either electrical stimulation or vasoconstricting agents were reduced or abolished by reducing the concentration of the Ca in the medium. The Ca response was dose-dependent and reversed at a high concentration. Contractions induced by vasoconstrictors were more resistant to the change of the Ca concentration than by electrical stimulation. Verapamil, a blocker of Ca entry, inhibited the contraction by simulating Ca depletion. These changes show that the extent of Ca influx regulates the smooth-muscle contraction of the nasal blood vessels consistent with the reports concerning other vascular smooth muscle.
对犬类体外鼻血管制剂进行测试，以确定钙（Ca）对平滑肌收缩的影响。通过降低培养基中钙的浓度，电刺激或血管收缩剂诱导的收缩会减弱或消除。钙反应呈剂量依赖性，在高浓度时会逆转。血管收缩剂诱导的收缩比电刺激诱导的收缩对钙浓度变化的抵抗力更强。钙通道阻滞剂维拉帕米通过模拟钙耗竭来抑制收缩。这些变化表明，钙内流的程度调节鼻血管的平滑肌收缩，这与关于其他血管平滑肌的报道一致。
