蛋白质合成抑制过程中组蛋白mRNA水平升高。

Increased histone mRNA levels during inhibition of protein synthesis.

作者信息

Stimac E, Groppi V E, Coffino P

出版信息

Biochem Biophys Res Commun. 1983 Jul 18;114(1):131-7. doi: 10.1016/0006-291x(83)91604-2.

Abstract

Inhibition of protein synthesis by cycloheximide or puromycin specifically increases the amount of translatable histone mRNA in exponentially growing and in synchronous G1 HeLa cells by 5-fold in 3 hours. In this case histone gene expression is uncoupled from DNA replication. We conclude that the level of histone mRNA is regulated by a labile protein and is only indirectly dependent on DNA synthesis.

摘要

放线菌酮或嘌呤霉素对蛋白质合成的抑制作用，能使指数生长的和处于同步G1期的海拉细胞中可翻译的组蛋白mRNA的量在3小时内特异性增加5倍。在这种情况下，组蛋白基因表达与DNA复制解偶联。我们得出结论，组蛋白mRNA的水平受一种不稳定蛋白质的调节，并且只是间接地依赖于DNA合成。