Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80525.
Program in Cell & Molecular Biology, Colorado State University, Fort Collins, Colorado 80525.
Cold Spring Harb Perspect Biol. 2018 May 1;10(5):a032839. doi: 10.1101/cshperspect.a032839.
RNA decay plays a major role in regulating gene expression and is tightly networked with other aspects of gene expression to effectively coordinate post-transcriptional regulation. The goal of this work is to provide an overview of the major factors and pathways of general messenger RNA (mRNA) decay in eukaryotic cells, and then discuss the effective interplay of this cytoplasmic process with the protein synthesis machinery. Given the transcript-specific and fluid nature of mRNA stability in response to changing cellular conditions, understanding the fundamental networking between RNA decay and translation will provide a foundation for a complete mechanistic understanding of this important aspect of cell biology.
RNA 衰变在调节基因表达方面起着重要作用，并且与基因表达的其他方面紧密相连，以有效地协调转录后调控。这项工作的目的是概述真核细胞中一般信使 RNA（mRNA）衰变的主要因素和途径，然后讨论这个细胞质过程与蛋白质合成机制的有效相互作用。鉴于转录本特异性和 mRNA 稳定性对细胞状态变化的响应的动态性质，理解 RNA 衰变和翻译之间的基本网络将为全面理解细胞生物学的这一重要方面提供基础。
