Yang N C, Hrinyo T P, Petrich J W, Yang D D
Biochem Biophys Res Commun. 1983 Jul 18;114(1):8-13. doi: 10.1016/0006-291x(83)91586-3.
The interactions between DOBP (3) and calf thymus DNA as well as four synthetic polynucleotides, poly(dA-dT), polydA:polydT, poly(dG-dC), and polydG:polydC, were investigated by spectroscopic techniques. It was found that the binding of 3 with poly(dA-dT) is favored appreciably over other synthetic polynucleotides and DNA. The results suggest that the initial association of carcinogenic BPDE (2) with DNA may take place preferentially at certain specific base sequences in DNA.
通过光谱技术研究了DOBP（3）与小牛胸腺DNA以及四种合成多核苷酸poly（dA-dT）、polydA:polydT、poly（dG-dC）和polydG:polydC之间的相互作用。结果发现，与其他合成多核苷酸和DNA相比，3与poly（dA-dT）的结合明显更受青睐。结果表明，致癌性BPDE（2）与DNA的初始结合可能优先发生在DNA的某些特定碱基序列处。
