将钴对δ-氨基-γ-酮戊酸合酶活性的抑制作用与细胞内卟啉浓度相关联的证据。
Evidence relating the inhibitory effect of cobalt on the activity of delta-aminolevulinate synthase to the intracellular concentration of porphyrins.
作者信息
Schoenfeld N, Greenblat Y, Epstein O, Tschudy D P, Atsmon A
出版信息
Biochem Pharmacol. 1983 Aug 1;32(15):2333-7. doi: 10.1016/0006-2952(83)90182-x.
PMID:6882472
Abstract
This study shows that the inhibition of ALAS activity caused by cobalt is directly correlated with the intracellular porphyrin concentration, thus indicating that cobalt exerts its inhibitory effect on ALAS activity as a result of the formation of cobalt-protoporphyrin.
摘要
这项研究表明，钴对δ-氨基-γ-酮戊酸合成酶（ALAS）活性的抑制作用与细胞内卟啉浓度直接相关，因此表明钴通过形成钴原卟啉对ALAS活性发挥抑制作用。
Zotero 插件