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氯化钴和钴原卟啉给药对大鼠肝脏δ-氨基乙酰丙酸合酶的影响。

Effects of administration of cobalt chloride and cobalt protoporphyrin on delta-aminolevulinate synthase in rat liver.

作者信息

Igarashi J, Hayashi N, Kikuchi G

出版信息

J Biochem. 1978 Oct;84(4):997-1000. doi: 10.1093/oxfordjournals.jbchem.a132215.

DOI:10.1093/oxfordjournals.jbchem.a132215
PMID:711712
Abstract

Cobalt protoporphyrin inhibited the drug-induced increase of delta-aminolevulinate synthase as well as its transfer from the cytosol fraction to the mitochondria in rat liver in a similar way to protoheme. Cobalt chloride given to animals in a large dose exhibited similar effects. Cobalt protoporphyrin was isolated from the liver of rats treated with cobalt chloride. The observed regulatory effects of cobalt chloride with respect to the induction and the intracellular translocation of delta-aminolevulinate synthase may be mediated by cobalt protoporphyrin synthesized in vivo.

摘要

钴原卟啉抑制药物诱导的大鼠肝脏中δ-氨基乙酰丙酸合酶增加及其从胞浆部分向线粒体的转移，其作用方式与原血红素相似。给动物大剂量注射氯化钴也表现出类似的效果。从用氯化钴处理的大鼠肝脏中分离出了钴原卟啉。观察到的氯化钴对δ-氨基乙酰丙酸合酶诱导和细胞内转运的调节作用可能是由体内合成的钴原卟啉介导的。

相似文献

1
Effects of administration of cobalt chloride and cobalt protoporphyrin on delta-aminolevulinate synthase in rat liver.氯化钴和钴原卟啉给药对大鼠肝脏δ-氨基乙酰丙酸合酶的影响。
J Biochem. 1978 Oct;84(4):997-1000. doi: 10.1093/oxfordjournals.jbchem.a132215.
2
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Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.血红素对肝脏中δ-氨基-γ-酮戊酸合酶合成及细胞内转运的调控
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Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt.大鼠肝脏中钴原卟啉的形成。无机钴抑制肝脏血红素生物合成的机制。
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Evidence relating the inhibitory effect of cobalt on the activity of delta-aminolevulinate synthase to the intracellular concentration of porphyrins.将钴对δ-氨基-γ-酮戊酸合酶活性的抑制作用与细胞内卟啉浓度相关联的证据。
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[Effect of cobalt chloride on the activity of key enzymes of heme metabolism in the rat liver].[氯化钴对大鼠肝脏血红素代谢关键酶活性的影响]
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Effect of cobalt on heme biosynthesis in rat liver and spleen.
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Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications.锡原卟啉抑制化学诱导的实验性肝卟啉症。潜在的临床意义。
J Clin Invest. 1985 Dec;76(6):2436-9. doi: 10.1172/JCI112259.

引用本文的文献

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Mol Cell Biochem. 2008 Dec;319(1-2):153-61. doi: 10.1007/s11010-008-9888-0. Epub 2008 Aug 22.
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Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin.钴对肝细胞色素P-450的降低作用。钴原卟啉作用的证据。
Biochem J. 1982 Apr 15;204(1):103-9. doi: 10.1042/bj2040103.
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Control of delta-aminolaevulinate synthase and haem oxygenase in chronic-iron-overloaded rats.
慢性铁过载大鼠中δ-氨基乙酰丙酸合酶和血红素加氧酶的调控
Biochem J. 1981 Oct 15;200(1):35-42. doi: 10.1042/bj2000035.
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Mol Cell Biochem. 1983;53-54(1-2):163-83. doi: 10.1007/BF00225252.
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Biochem J. 1981 Apr 15;196(1):285-92. doi: 10.1042/bj1960285.
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