放射增敏剂增强细胞毒性药物的作用。
Enhancement of the effect of cytotoxic drugs by radiosensitizers.
作者信息
Martin W M, McNally N J, De Ronde J
出版信息
Br J Cancer. 1981 Jun;43(6):756-66. doi: 10.1038/bjc.1981.113.
Abstract
Misonidazole (MISO) potentiates the action of cyclophosphamide (CY) and melphalan in the WHFIB culture-adapted fibrosarcoma, whether assayed by cell survival or tumour-growth delay. In the case of CY, MISO also inhibited recovery from potentially lethal drug damage. The optimum effect was seen when MISO was given 1 h before CY, though it was also effective when given 6 h before or 1 h after the drug. Other radiosensitizers also potentiated the action of CY. There was only a small effect of MISO on the LD50 of CY and no effect on CY toxicity as assayed by changes in blood counts or damage to bladder epithelium. However, mice bearing multiple lung tumours were less able to cope with the combined treatment than those bearing s.c. tumours.
摘要
灭癌肼（MISO）可增强环磷酰胺（CY）和美法仑对适应于WHFIB培养的纤维肉瘤的作用，无论通过细胞存活还是肿瘤生长延迟来测定。就CY而言，MISO还可抑制潜在致死性药物损伤后的恢复。当在CY给药前1小时给予MISO时可观察到最佳效果，不过在药物给药前6小时或给药后1小时给予MISO也有效。其他放射增敏剂也可增强CY的作用。MISO对CY的半数致死量（LD50）仅有轻微影响，且对通过血细胞计数变化或膀胱上皮损伤所测定的CY毒性无影响。然而，患有多发性肺肿瘤的小鼠比患有皮下肿瘤的小鼠更难以应对联合治疗。
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