Knoll G, Brdiczka D
Biochim Biophys Acta. 1983 Aug 24;733(1):102-10. doi: 10.1016/0005-2736(83)90095-0.
Structural changes of mitochondria in correlation to their energetic state have been observed as matrix expansion and condensation. In this communication we describe a morphological correlation in freeze-fractured mitochondrial membranes which is also dependent on the metabolic state of the organelle: the frequency by which the fracture plane following the inner or outer boundary membrane deviates by jumping from one membrane to the other is higher in phosphorylating mitochondria when compared to freshly isolated or energized mitochondria. These deflections of the fracture plane occur mostly in minimal, short steps showing close apposition of the two boundary membranes. We therefore conclude that the observed change in morphological appearance is produced by a change in interactions between the inner and outer membranes correlated to the different functional states of the inner membrane.
线粒体的结构变化与其能量状态相关，已观察到表现为基质扩张和浓缩。在本通讯中，我们描述了冷冻断裂线粒体膜中的一种形态学关联，其也取决于细胞器的代谢状态：与新鲜分离或供能的线粒体相比，在进行磷酸化的线粒体中，沿着内或外边界膜的断裂平面通过从一层膜跳到另一层膜而发生偏离的频率更高。断裂平面的这些偏移大多以最小的短步长出现，表明两层边界膜紧密贴靠。因此，我们得出结论，观察到的形态外观变化是由内膜和外膜之间相互作用的变化产生的，这种变化与内膜的不同功能状态相关。
