出生后缺氧对新生大鼠早期新生儿期能量稳态的影响。

Effect of postnatal hypoxia on the energy homeostasis of the newborn rat during the early neonatal period.

作者信息

Arizmendi C, Maties M, Benito M, Medina J M

出版信息

Biol Neonate. 1983;44(1):36-41. doi: 10.1159/000241692.

Abstract

Newborn rats breathing a low-oxygen mixture showed similar rates of glycogenolysis to newborns breathing air. However, hypoxia prevented the decrease of plasma glucose and lactate concentrations which occurred in newborns breathing air immediately after delivery. The time-course of plasma alanine was not affected by experimental hypoxia. The decrease in the liver lactate/pyruvate ratio observed in control newborns immediately after delivery was prevented by hypoxia. Lower blood oxygen concentrations were observed in hypoxic animals throughout the observation period. Lower ATP concentrations were observed in hypoxic newborns during the first hour after delivery but similar values were observed in both groups thereafter.

摘要

呼吸低氧混合气体的新生大鼠，其糖原分解速率与呼吸空气的新生大鼠相似。然而，缺氧阻止了出生后立即呼吸空气的新生大鼠血浆葡萄糖和乳酸浓度的降低。血浆丙氨酸的时间进程不受实验性缺氧的影响。缺氧阻止了对照新生大鼠出生后立即观察到的肝脏乳酸/丙酮酸比值的降低。在整个观察期内，缺氧动物的血氧浓度较低。缺氧新生大鼠在出生后第一小时内ATP浓度较低，但此后两组的ATP浓度相似。