大鼠早产。III. 氧气供应的影响。

Prematurity in the rat. III. Effect of oxygen supply.

作者信息

Cuezva J M, Medina J M

出版信息

Biol Neonate. 1981;39(1-2):70-7. doi: 10.1159/000241394.

Abstract

Changes in liver glycogen, plasma glucose, lactate, alanine and glycerol concentrations in term and preterm newborn rats breathing pure oxygen have been studied. The time courses of lactate and pyruvate concentrations in the livers of term and preterm rats breathing air or pure oxygen have also been investigated. The increased oxygen supply enhanced plasma glucose, lactate and alanine utilization while the rate of glycogenolysis was not effected. In these conditions, the resistance to lactate utilization observed in preterm newborns breathing air was overcome. The liver lactate/pyruvate ratio sharply decreased immediately after delivery in term and preterm rats breathing pure oxygen and in term rats breathing air. However, this decrease was delayed for 30 min in preterm newborns breathing air. These results suggest that the preterm rat suffers a defective oxygen supply to the tissues which results in a transient resistance to lactate utilization.

摘要

已对足月和早产新生大鼠呼吸纯氧时肝糖原、血糖、乳酸、丙氨酸和甘油浓度的变化进行了研究。还研究了足月和早产大鼠呼吸空气或纯氧时肝脏中乳酸和丙酮酸浓度的时间进程。氧气供应增加增强了血糖、乳酸和丙氨酸的利用，而糖原分解速率未受影响。在这些条件下，呼吸空气的早产新生儿中观察到的对乳酸利用的抗性被克服。呼吸纯氧的足月和早产大鼠以及呼吸空气的足月大鼠在出生后肝脏乳酸/丙酮酸比值立即急剧下降。然而，呼吸空气的早产新生儿中这种下降延迟了30分钟。这些结果表明，早产大鼠存在组织供氧缺陷，导致对乳酸利用产生短暂抗性。