Terpin T, Roach M R
Can J Physiol Pharmacol. 1983 May;61(5):502-6. doi: 10.1139/y83-076.
Sixteen New Zealand White rabbits with an average initial weight of 1.6 kg were used to determine if lathyrism altered the static elastic properties of the aorta and carotid arteries. Eight were given 1% beta-aminopropionitrile in their drinking water for the same period. All were fed regular rabbit chow. Blood pressures and body weights were taken twice weekly. Blood pressure was not significantly different between the two groups but the lathyritic animals did lose weight while the controls gained. The rabbits were sacrificed at the end of 4 weeks with an overdose of sodium pentobarbital (Nembutal) and the carotid arteries and thoracic aorta were removed for pressure--volume experiments. From these experiments tension--strain curves, elasticities, and slack of the collagen were obtained. The longitudinal distensibility curves for the aortas and carotid arteries for both groups were almost identical. The longitudinal elasticities of elastin and collagen, and the slack were not significantly different between the two groups. The circumferential-distensibility curves for the same arteries showed few differences, however, the elasticities of elastin and collagen, and the slack decreased indicating an alteration in the elastin and a decrease in collagen fibres or a defect in the intramolecular cross-links of collagen.
选用16只平均初始体重为1.6千克的新西兰白兔，以确定山黧豆中毒是否会改变主动脉和颈动脉的静态弹性特性。8只兔子在同一时期饮用含1%β-氨基丙腈的水。所有兔子均喂食常规兔粮。每周测量两次血压和体重。两组之间血压无显著差异，但患山黧豆中毒的兔子体重下降，而对照组体重增加。4周结束时，过量注射戊巴比妥钠（戊巴比妥）处死兔子，取出颈动脉和胸主动脉进行压力-容积实验。通过这些实验获得了张力-应变曲线、弹性和胶原蛋白的松弛度。两组主动脉和颈动脉的纵向扩张性曲线几乎相同。两组之间弹性蛋白和胶原蛋白的纵向弹性以及松弛度无显著差异。相同动脉的周向扩张性曲线显示差异不大，然而，弹性蛋白和胶原蛋白的弹性以及松弛度降低，表明弹性蛋白发生改变，胶原蛋白纤维减少或胶原蛋白分子内交联存在缺陷。
