Terpin T, Roach M R
Can J Physiol Pharmacol. 1987 Mar;65(3):395-400. doi: 10.1139/y87-066.
These experiments were designed to determine if local differences in elastic properties or wall structure contributed to the development of aortic rupture in turkeys. Static elastic properties were measured from pressure-volume curves of cylindrical segments of upper and lower thoracic aorta and innominate artery in two groups of lathyritic birds and two age-matched control groups. The biggest changes were in the young lathyritic group that was on 0.04% beta-aminoproprionitrile at 3 weeks of age and continued for 2, 3, or 4 weeks. Much smaller changes were seen in the older group that started on 0.05% beta-aminoproprionitrile at 6 weeks of age for 10 days and then 0.02% beta-aminoproprionitrile for the next 9-12 weeks. The biggest changes were seen in the abdominal aorta, which ruptured spontaneously in 50% of the young lathyritic group. The birds had a marked decrease in the number of elastin layers per unit wall thickness. Analysis of the elastic diagrams showed that the elastance of both elastin and collagen were altered in the young lathyritic group. Rupture appeared to follow partial dissection of plaques, but true longitudinal dissection did not occur.
这些实验旨在确定弹性特性或血管壁结构的局部差异是否会导致火鸡主动脉破裂的发生。在两组患骨生成障碍病的禽类和两组年龄匹配的对照组中，从胸主动脉上下段和无名动脉的圆柱形节段的压力-容积曲线测量静态弹性特性。变化最大的是3周龄时摄入0.04%β-氨基丙腈并持续2、3或4周的年轻患骨生成障碍病组。变化小得多的是6周龄时开始摄入0.05%β-氨基丙腈10天，然后在接下来的9至12周摄入0.02%β-氨基丙腈的老年组。变化最大的是腹主动脉，在50%的年轻患骨生成障碍病组中腹主动脉会自发破裂。这些禽类每单位壁厚度的弹性蛋白层数显著减少。弹性图分析表明，年轻患骨生成障碍病组中弹性蛋白和胶原蛋白的弹性都发生了改变。破裂似乎是在斑块部分剥离后发生的，但并未出现真正的纵向剥离。
