Sipponen P, Kekki M, Siurala M
Cancer. 1983 Sep 15;52(6):1062-8. doi: 10.1002/1097-0142(19830915)52:6<1062::aid-cncr2820520622>3.0.co;2-p.
The occurrence of chronic gastritis and intestinal metaplasia (IM) was studied in 257 patients with gastric carcinoma (GC). In all cases biopsies were available from the benign mucosal area adjacent to the tumor, and in 139 patients from the antrum and/or body mucosa outside the tumor. The results were compared with endoscopically and bioptically examined noncancer controls representing a large Finnish population sample. For every GC patient, a control subject was matched by age and sex. In addition, a mean age-adjusted score (AAS) of chronic gastritis, which expresses the progression of gastritis in GC patients as compared with that in the general population, was calculated for GC patients. The prevalences of chronic and atrophic gastritis in the antrum and body mucosa were similar in GC patients and controls when carcinoma cases were not more specifically classified according to histologic type or location of tumors. On the other hand, the location of the tumor showed a significant relation to gastritis: the progression of gastritis was more rapid (high mean AAS value) and the prevalence of atrophic gastritis was higher in the tumor-affected area (i.e., in the antrum in patients with antral [distal] tumors; in the body in patients with body [proximal] tumors), than in the general population, but were similar in the tumor-free area in both GC patients and controls. In the intestinal type of GC (IGC), the prevalence of chronic gastritis was higher and its progression was more rapid than in controls. In the diffuse type of GC (DGC), these correlations were less distinct. In GC patients, the IM adjacent to and outside the tumor area was significantly more common and extensive than in the corresponding area of controls, and a significant positive correlation was present between the location of the tumor and the distribution of IM. Like gastritis, the IM showed a closer relationship to IGC than to DGC. In all cases of GC and particularly of IGC, the antral mucosa tended to be more severely affected by gastritis and IM than the body mucosa, i.e., the prevailing type of gastritis found in this GC series was that morphologically corresponding to the so-called B-type of chronic gastritis.
对257例胃癌（GC）患者的慢性胃炎和肠化生（IM）情况进行了研究。所有病例均获取了肿瘤旁良性黏膜区域的活检样本，139例患者还获取了肿瘤外胃窦和/或胃体黏膜的活检样本。将结果与代表芬兰大量人群样本的经内镜和活检检查的非癌症对照进行比较。为每位GC患者匹配了年龄和性别相同的对照对象。此外，还为GC患者计算了慢性胃炎的平均年龄校正评分（AAS），该评分表示GC患者胃炎进展情况与普通人群的比较。当癌病例未根据组织学类型或肿瘤位置进行更具体分类时，GC患者和对照中胃窦和胃体黏膜慢性和萎缩性胃炎的患病率相似。另一方面，肿瘤位置与胃炎存在显著关系：胃炎进展更快（平均AAS值高），且萎缩性胃炎患病率在肿瘤受累区域（即胃窦部肿瘤患者的胃窦；胃体部肿瘤患者的胃体）高于普通人群，但在GC患者和对照的无肿瘤区域相似。在肠型GC（IGC）中，慢性胃炎患病率高于对照且进展更快。在弥漫型GC（DGC）中，这些相关性不太明显。在GC患者中，肿瘤区域及以外的IM比对照相应区域显著更常见且范围更广，肿瘤位置与IM分布之间存在显著正相关。与胃炎一样，IM与IGC的关系比与DGC更密切。在所有GC病例尤其是IGC病例中，胃窦黏膜比胃体黏膜受胃炎和IM的影响更严重，即该GC系列中常见的胃炎类型在形态上对应于所谓的B型慢性胃炎。
