Anderström C, Johansson S L, von Schultz L
Cancer. 1983 Oct 1;52(7):1273-80. doi: 10.1002/1097-0142(19831001)52:7<1273::aid-cncr2820520724>3.0.co;2-7.
The study is a clinicopathologic report on 64 patients with primary adenocarcinoma of the urinary bladder and urachus, with particular reference to important prognostic and therapeutic factors. All tumors exhibited adenocarcinomatous features in at least two thirds of the examined tumor area. Pure forms of the different histological patterns were seen in 50% of the cases and in the remaining tumors a mixture was recorded. Poorly differentiated tumors were found in 41 cases. All tumors were invasive and in 40 cases the tumors penetrated through the bladder wall. The pattern and frequency of metastasis was similar to that of conventional bladder tumors of high stage. The prognosis for patients with primary adenocarcinoma of the bladder was poor and the 5-year survival rate in this study was 18%. Important prognostic factors were tumor stage, size and grade and treatment. The location of the tumor seemed less important and tumors located in the dome or anterior wall did not indicate a poorer prognosis. The adenocarcinomas of the urinary bladder were predominantly solitary tumors. They were poorly differentiated, deeply invasive large tumors associated with an exceedingly poor prognosis. Partial bladder resection appears to be adequate therapy only in patients with moderately well differentiated small tumors. In other cases more radical therapy must be considered.
这项研究是一份关于64例原发性膀胱和脐尿管腺癌患者的临床病理报告，特别提及了重要的预后和治疗因素。所有肿瘤在至少三分之二的检查肿瘤区域呈现腺癌特征。50%的病例可见不同组织学模式的纯形式，其余肿瘤则记录为混合形式。41例肿瘤分化不良。所有肿瘤均具有侵袭性，40例肿瘤穿透膀胱壁。转移模式和频率与高分期传统膀胱肿瘤相似。膀胱原发性腺癌患者的预后较差，本研究中的5年生存率为18%。重要的预后因素包括肿瘤分期、大小、分级和治疗。肿瘤位置似乎不太重要，位于膀胱顶部或前壁的肿瘤并未提示预后更差。膀胱腺癌主要为孤立性肿瘤。它们分化不良、侵袭性深、体积大，预后极差。部分膀胱切除术似乎仅对中度分化良好的小肿瘤患者是足够的治疗方法。在其他情况下，必须考虑更彻底的治疗。
