Taniwaki M, Edagawa J, Sonoda Y, Nishida K, Misawa S, Abe T, Takino T, Arizono N
Cancer Genet Cytogenet. 1983 Sep;10(1):59-65. doi: 10.1016/0165-4608(83)90106-1.
A 70-year-old Japanese male with hemopoietic dysplasia is described. Cytogenetic investigation revealed an abnormal karyotype, 46,XY,del(5)(q13q33), in all metaphases examined at the time of diagnosis. Eight months later, a newly appearing abnormal hyperdiploid karyotype, 47,XY,5q-, +21, was observed in 74% of the cells analyzed, which was associated with evolution of the disease when a pathologic diagnosis of a myeloproliferative disorder was made.
本文描述了一名患有造血发育异常的70岁日本男性。细胞遗传学检查显示，在诊断时所检查的所有中期分裂相中，核型异常为46,XY,del(5)(q13q33)。8个月后，在分析的74%的细胞中观察到一种新出现的异常超二倍体核型47,XY,5q-, +21，在做出骨髓增殖性疾病的病理诊断时，这与疾病进展相关。
