Holaday D A
Contemp Anesth Pract. 1983;7:45-59.
Sevoflurane is nonexplosive and, in clinically useful concentrations, nonflammable. It is relatively chemically inert in that it can be stored without preservative, and undergoes limited dehydrofluorination in moist alkali. It does not sensitize the heart to epinephrine or cause alterations of hematologic or serum clinical chemistry values after repeated exposures in animals or in man after a single exposure. It depresses respiration and cardiovascular functions in experimental animals and man, but less than halothane. It is metabolized to a limited extent, releasing subnephrotoxic amounts of fluoride ion. Sevoflurane warrants further testing in man.
七氟烷不易爆炸，在临床常用浓度下不可燃。它化学性质相对稳定，无需添加防腐剂即可储存，在潮湿碱性环境中仅发生有限的脱氟化氢反应。它不会使心脏对肾上腺素敏感，也不会在动物反复接触或人类单次接触后导致血液学或血清临床化学值改变。在实验动物和人类中，它会抑制呼吸和心血管功能，但比氟烷的抑制作用小。它仅在有限程度上被代谢，释放出低于肾毒性剂量的氟离子。七氟烷值得在人体中进行进一步测试。
