Kitamura K, Kinehara M, Tamura N, Nakamura K
Cutis. 1983 Jul;32(1):83-4, 86-8.
Hidroacanthoma simplex is a benign tumor of the skin, macroscopically resembling seborrheic keratosis or Bowen's disease, and histologically revealing intraepidermal focal growth of epithelial cells. A case of hidroacanthoma simplex with a malignant portion is presented in this report. The present case revealed mostly histologic characteristics of hidroacanthoma simplex, but the central portion of the tumor showed downward invasive growth with increased cellular atypia. The malignant change of hidroacanthoma simplex is discussed in relation to eccrine porocarcinoma (malignant eccrine poroma).
单纯性汗腺棘皮瘤是一种皮肤良性肿瘤，肉眼上类似于脂溢性角化病或鲍温病，组织学上显示上皮细胞在表皮内呈局灶性生长。本报告展示了一例伴有恶性成分的单纯性汗腺棘皮瘤病例。该病例大多显示出单纯性汗腺棘皮瘤的组织学特征，但肿瘤中央部分表现为向下浸润性生长，细胞异型性增加。结合小汗腺汗孔癌（恶性小汗腺汗孔瘤）对单纯性汗腺棘皮瘤的恶性变化进行了讨论。
