Brown E J, Holman B L, Wynne J, Swinford R, Cohn P F
Chest. 1983 Sep;84(3):258-63. doi: 10.1378/chest.84.3.258.
In order to evaluate the effects of timolol, a new beta-adrenergic blocking agent, on exercise-induced left ventricular wall motion abnormalities, we studied nine patients with chronic, angiographically-documented coronary artery disease. A computerized technique for determining apical, anteroseptal and inferoposterior regional ejection fractions during gated radionuclide ventriculography was used to assess left ventricular dysfunction. During exercise prior to the administration of timolol, the apical regional ejection fraction fell from 0.62 +/- 0.08 to 0.51 +/- 0.08 (p less than .01). The anteroseptal ejection fraction fell from 0.50 +/- 0.08 to 0.41 +/- 0.05 (p less than .05), and the inferoposterior ejection fraction fell from 0.75 +/- 0.10 to 0.59 +/- 0.06 (p less than .05). Three days after beginning therapy with 10-30 mg of timolol, this reduction was markedly attenuated. The apical ejection fraction fell from 0.59 +/- 0.09 to 0.54 +/- 0.08 (p = NS), the anteroseptal ejection fraction fell from 0.49 +/- 0.07 to 0.47 +/- 0.18 (p = NS) and the inferoposterior ejection fraction fell from 0.62 +/- 0.06 to 0.59 +/- 0.07 (p = NS). Furthermore, several individual regions showed increases in ejection fraction. This study demonstrates a previously unreported and beneficial anti-ischemic effect of timolol.
为了评估新型β-肾上腺素能阻滞剂噻吗洛尔对运动诱发的左心室壁运动异常的影响，我们研究了9例经血管造影证实患有慢性冠状动脉疾病的患者。采用计算机技术在门控放射性核素心室造影期间测定心尖、前间隔和下后壁区域射血分数，以评估左心室功能障碍。在给予噻吗洛尔之前的运动期间，心尖区域射血分数从0.62±0.08降至0.51±0.08（p＜0.01）。前间隔射血分数从0.50±0.08降至0.41±0.05（p＜0.05），下后壁射血分数从0.75±0.10降至0.59±0.06（p＜0.05）。开始用10 - 30mg噻吗洛尔治疗三天后，这种降低明显减弱。心尖射血分数从0.59±0.09降至0.54±0.08（p =无显著性差异），前间隔射血分数从0.49±0.07降至0.47±0.18（p =无显著性差异），下后壁射血分数从0.62±0.06降至0.59±0.07（p =无显著性差异）。此外，几个单独区域的射血分数有所增加。本研究证明了噻吗洛尔以前未报道的有益抗缺血作用。
