McCabe M, Maguire D, Nowak M
Environ Res. 1983 Aug;31(2):323-31. doi: 10.1016/0013-9351(83)90010-5.
The response of human and bovine peripheral blood lymphocytes to PHA stimulation was measured in the presence of low concentrations of sodium arsenite and sodium arsenate. In bovine lymphocytes, 41% augmentation of the response occurred at 10(-6) M arsenite with a return to the normal response at 2.5 X 10(-6) M. Complete inhibition of mitogenesis occurred at 6 X 10(-6) M. In the presence of sodium arsenate, similar results were obtained but at the higher concentrations of 2 X 10(-5) (for 57% augmentation), 5.2 X 10(-5), and 1.9 X 10(-4) M, respectively. The possible significance of these findings in view of the known relationship between chronic arsenicalism and human skin cancer is discussed. It is suggested that arsenic compounds may, by potentiating mitogenesis, increase the possibility of errors in DNA replication, some of which could be potentially carcinogenic. Additionally, interference with the immune response could enable potentially cancerous cells to escape immune surveillance.
在低浓度亚砷酸钠和砷酸钠存在的情况下，测定了人和牛外周血淋巴细胞对PHA刺激的反应。在牛淋巴细胞中，10(-6) M亚砷酸盐时反应增强41%，在2.5×10(-6) M时恢复正常反应。在6×10(-6) M时丝裂原生成完全被抑制。在砷酸钠存在的情况下，获得了类似的结果，但分别在2×10(-5)（反应增强57%）、5.2×10(-5)和1.9×10(-4) M的较高浓度下。鉴于慢性砷中毒与人类皮肤癌之间的已知关系，讨论了这些发现的可能意义。有人提出，砷化合物可能通过增强有丝分裂，增加DNA复制错误的可能性，其中一些可能具有潜在致癌性。此外，对免疫反应的干扰可能使潜在的癌细胞逃避免疫监视。
