Blakley B R
Can J Vet Res. 1987 Apr;51(2):240-3.
Female Swiss mice were exposed to sodium arsenite or sodium aresenate in the drinking water for 15 weeks at concentrations ranging from 0 to 100 micrograms/mL arsenic content. After three weeks of the 15 week exposure period, the mice were administered urethan (1.5 mg/g) intraperitoneally. Pulmonary adenoma formation was evaluated 12 weeks later. Arsenic exposure produced a protective effect with respect to tumor development. Both forms of arsenic reduced the size and number of pulmonary adenomas observed per mouse. In addition, urethan-induced sleeping times which reflect the rate of urethan metabolism or excretion remained unchanged. This suggests that arsenic exposure does not alter urethan excretion and is not a factor influencing subsequent adenoma formation of these levels of exposure.
将雌性瑞士小鼠置于饮用水中含砷量为0至100微克/毫升的亚砷酸钠或砷酸钠环境中15周。在15周暴露期的3周后，给小鼠腹腔注射乌拉坦（1.5毫克/克）。12周后评估肺腺瘤的形成情况。砷暴露对肿瘤发展产生了保护作用。两种形式的砷都减少了每只小鼠观察到的肺腺瘤的大小和数量。此外，反映乌拉坦代谢或排泄速率的乌拉坦诱导睡眠时间保持不变。这表明砷暴露不会改变乌拉坦的排泄，且不是影响这些暴露水平后续腺瘤形成的一个因素。
