低热值煤气化炉焦油对肺泡巨噬细胞的体外细胞毒性

In vitro cytotoxicity to alveolar macrophages of tar from a low-Btu coal gasifier.

作者信息

Hill J O, Royer R E, Mitchell C E, Dutcher J S

出版信息

Environ Res. 1983 Aug;31(2):484-92. doi: 10.1016/0013-9351(83)90026-9.

Abstract

The cytotoxicity of fractions, subfractions, and some individual components present in tar from a low-Btu coal gasifier was determined in vitro with cultured dog alveolar macrophages. A subfraction of the tar which contained phenols and neutral nitrogen heterocycles was found to be a major contributor to the cytotoxic activity of the tar. Four compounds present in this subfraction were tested individually. Ranked from the most to the least toxic they were: 9-phenanthrol, 2-fluorenol, phenanthridone, and carbazole.

摘要

采用培养的犬肺泡巨噬细胞，在体外测定了来自低热量煤气化炉的焦油中各馏分、亚馏分和一些单个成分的细胞毒性。发现焦油中含有酚类和中性氮杂环的一个亚馏分是焦油细胞毒性活性的主要贡献者。对该亚馏分中存在的四种化合物进行了单独测试。从毒性最大到最小排序依次为：9-菲醇、2-芴醇、菲啶酮和咔唑。