Kahn E, Aubert B, Parmentier C, Di Paola R
Eur J Nucl Med. 1983;8(7):312-6. doi: 10.1007/BF00253758.
The purpose of this study was to evaluate the feasibility of a method that would use 59Fe quantitative sequential scintigrams together with a few blood samples in place of conventional ferrokinetic studies. To quantitate the efficiency of erythropoiesis or iron deposition sites, the radio-iron blood activity was subtracted by means of a whole body scanning with 99mTc-labelled erythrocytes. The study was performed on 31 patients (36 examinations) and regions of interest were drawn by three physicians on the sacral bone, the liver, the spleen and the femoral bone. To assess the physical feasibility of the scintigraphic method, correlation coefficients were computed between the number of counts of the 59Fe and 99mTc images and the corresponding 99mTc and 59Fe activities. To assess the clinical feasibility, the consistency of the data resulting from the drawing of the ROIs was verified and those of conventional ferrokinetics were introduced and their consistency verified. These assessments suggest that the scintigraphic method can be used in place of the conventional external counting method.
本研究的目的是评估一种方法的可行性，该方法将使用59Fe定量序贯闪烁扫描图以及少量血样来替代传统的铁动力学研究。为了定量红细胞生成效率或铁沉积部位，通过用99mTc标记的红细胞进行全身扫描来减去放射性铁的血液活性。该研究对31例患者（36次检查）进行，三名医生在骶骨、肝脏、脾脏和股骨上绘制了感兴趣区域。为了评估闪烁扫描法的物理可行性，计算了59Fe和99mTc图像的计数数量与相应的99mTc和59Fe活性之间的相关系数。为了评估临床可行性，对感兴趣区域绘制所得到的数据的一致性进行了验证，并引入了传统铁动力学的数据并验证了其一致性。这些评估表明，闪烁扫描法可用于替代传统的外部计数法。
