Gupta M, Roth P, Werner E, Kaltwasser J P
Eur J Nucl Med. 1979 Feb 1;4(1):17-20. doi: 10.1007/BF00257564.
In this study, erythropoietic activity of bone marrow has been evaluated by ferrokinetics. For that purpose, the data of radioiron disappearance from plasma and its ultimate incorporation in red blood cells after the injection of about 10 muCi of 59Fe tagged autologous plasma, were analysed and fitted to the sum of three exponentials, using a non-linear least square SAAM-25 program on UNIVAC-1108 computer. A function representing time-activity relationship, was constructed. The functional physiological model of iron metabolism, proposed by Cavill and Ricketts, was used to calculate various ferrokinetic parameters in terms of coefficients and exponents of the time-activity function. After identifying the parameters that could be used as indices of erythropoietic activity of bone marrow, the study was repeated in six patients after they had undergone myelostimulative therapy. A distinct correlation was found between ferrokinetic observations and clinical and biochemical findings. It has been demonstrated that in histologically diagnosed cases with bone marrow hypoplasia, a further differentiation between pure aplasia and those with hypoplasia together with ineffective erythropoiesis was possible. This discrimination which is clinically very important, is only possible by means of kinetic investigations.
在本研究中，已通过铁动力学评估了骨髓的红细胞生成活性。为此，在注射约10微居里的59Fe标记自体血浆后，分析血浆中放射性铁的消失数据及其最终掺入红细胞的数据，并使用UNIVAC - 1108计算机上的非线性最小二乘SAAM - 25程序将其拟合为三个指数之和。构建了一个表示时间 - 活性关系的函数。采用Cavill和Ricketts提出的铁代谢功能生理模型，根据时间 - 活性函数的系数和指数计算各种铁动力学参数。在确定了可用作骨髓红细胞生成活性指标的参数后，对6例接受骨髓刺激治疗的患者重复了该研究。发现铁动力学观察结果与临床和生化发现之间存在明显相关性。已经证明，在组织学诊断为骨髓发育不全的病例中，可以进一步区分单纯发育不全和伴有无效红细胞生成的发育不全。这种在临床上非常重要的鉴别仅通过动力学研究才有可能实现。
