Zaki A E, Wardle E N, Canalese J, Ede R J, Williams R
Experientia. 1983 Sep 15;39(9):988-91. doi: 10.1007/BF01989765.
The effects of potentials toxins of hepatic coma on the blood-brain barrier (BBB) permeability of the rat have been examined using the Oldendorf technique. Classical toxins of hepatic failure such as ammonia, methyl octanoate, mercaptans, and phenol caused significant increases in BBB permeability. A slight increase in permeability occurred following infusion of peroxidized linoleic acid and unconjugated bilirubin but no increase after infusion of bile acids. E. coli endotoxin infused into rats following partial hepatectomy also increased the BBB permeability.
利用奥尔登多夫技术研究了肝昏迷潜在毒素对大鼠血脑屏障（BBB）通透性的影响。肝功能衰竭的典型毒素，如氨、辛酸甲酯、硫醇和苯酚，可导致血脑屏障通透性显著增加。注入过氧化亚油酸和未结合胆红素后，通透性略有增加，但注入胆汁酸后通透性未增加。部分肝切除术后给大鼠注入大肠杆菌内毒素也会增加血脑屏障的通透性。
