Canalese J, Gove C D, Gimson A E, Wilkinson S P, Wardle E N, Williams R
Gut. 1982 Apr;23(4):265-9. doi: 10.1136/gut.23.4.265.
Kupffer cell and hepatocyte function were studied in 36 patients with fulminant hepatic failure by measurement of clearance of 125I microaggregated albumin (125IMAA) and galactose, respectively. Both were impaired but there was no correlation with final outcome, although on sequential testing 48 hours later, those patients who survived had a significantly greater improvement in Kupffer cell and hepatocyte function. In six other patients with similar hepatocyte dysfunction but no encephalopathy, Kupffer cell function was not significantly different from that of controls. This is additional support for a possible relation between encephalopathy and damage to Kupffer cell function. The latter was also shown to correlate with renal failure; this is consistent with the suggestion that endotoxaemia is important in the pathogenesis of this complication.
通过分别测定125I微聚白蛋白（125IMAA）清除率和半乳糖清除率，对36例暴发性肝衰竭患者的库普弗细胞和肝细胞功能进行了研究。两者均受损，但与最终结局无相关性，不过在48小时后的连续检测中，存活患者的库普弗细胞和肝细胞功能有显著更大程度的改善。在另外6例有类似肝细胞功能障碍但无脑病的患者中，库普弗细胞功能与对照组无显著差异。这进一步支持了脑病与库普弗细胞功能损害之间可能存在的关系。后者还被证明与肾衰竭相关；这与内毒素血症在该并发症发病机制中很重要的观点一致。
