由AP（脱嘌呤/脱嘧啶）位点导致的链间DNA交联。
Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites.
作者信息
Goffin C, Verly W G
出版信息
FEBS Lett. 1983 Sep 5;161(1):140-4. doi: 10.1016/0014-5793(83)80747-9.
PMID:6884524
Abstract
Storage of a solution of DNA containing apurinic sites, even at 4 degrees C leads to the appearance of interstrand crosslinks. Possible biological consequences of these crosslinks, when they appear in cell DNA, are briefly discussed. Formation of interstrand crosslinks in DNA containing tritium-labelled thymine and kept in an aqueous solution might be due, at least partly, to the loss of bases by the autoirradiated DNA.
摘要
含有脱嘌呤位点的DNA溶液即使在4摄氏度下储存也会导致链间交联的出现。简要讨论了这些交联出现在细胞DNA中时可能产生的生物学后果。含有氚标记胸腺嘧啶并保存在水溶液中的DNA中链间交联的形成可能至少部分是由于自辐照DNA中碱基的丢失。
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