人类白细胞抗原（HLA）平衡选择的证据。
Evidence for balancing selection at HLA.
作者信息
Hedrick P W, Thomson G
出版信息
Genetics. 1983 Jul;104(3):449-56. doi: 10.1093/genetics/104.3.449.
Abstract
HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.
摘要
将来自22个群体的A和B位点的HLA数据与Ewens抽样理论的中性预期进行了比较。在44个案例中的25个案例中，纯合性显著低于预期。虽然许多因素可以以这种方式影响纯合性，但经过仔细研究，只有对称平衡选择似乎与这些数据一致。
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