一个选定基因座对连锁中性基因座的影响。
The effect of a selected locus on linked neutral loci.
作者信息
Thomson G
出版信息
Genetics. 1977 Apr;85(4):753-88. doi: 10.1093/genetics/85.4.753.
Abstract
The effects produced on linked neutral loci as a selected locus evolves towards its equilibrium value are considered. Significant effects on the neutral loci arise if the recombination fraction between the neutral and selected loci is smaller than the order of magnitude of the selective differences at the selected locus. The effect on gene frequencies at the neutral loci, that is, the hitchhiking effect, is determined, as well as the linkage disequilibrium generated by this hitchhiking effect. One of the more important findings is that significant disequilibrium can be generated between two neutral loci by the evolution of a linked selected locus. Consideration is given to the problem of determining how the effect of selection operating in natural populations can be detected, the question of the establishment of inversions in populations, and also to the nonequilibrium properties of populations.
摘要
考虑了随着一个被选择的基因座朝着其平衡值进化时，对连锁中性基因座产生的影响。如果中性基因座与被选择基因座之间的重组率小于被选择基因座上选择差异的数量级，就会对中性基因座产生显著影响。确定了对中性基因座基因频率的影响，即搭便车效应，以及由这种搭便车效应产生的连锁不平衡。更重要的发现之一是，一个连锁的被选择基因座的进化可以在两个中性基因座之间产生显著的不平衡。还考虑了如何检测自然种群中选择作用的影响这一问题、种群中倒位的建立问题，以及种群的非平衡特性。
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