Morvay J, Altorjay I, Sas M
Horm Res. 1983;17(4):181-4. doi: 10.1159/000179696.
In the presence of ethynodiol diacetate the ethynylestradiol concentration in serum and saliva after oral administration was measured by a rapid radioimmunoassay method developed by the authors. By means of the saliva/serum quotient, and from the concentration of ethynylestradiol in the saliva samples, it was possible to infer the ethynylestradiol content of the serum. Attention is called to the relation between the quotient and time, which should be taken into account when values are calculated. 2, 4 and 12 h after oral administration, the saliva/serum quotients for an ethynylestradiol dose of 0.05 mg were 0.27, 0.76 and 0.40, respectively.
在乙炔雌二醇二乙酸酯存在的情况下，采用作者开发的快速放射免疫分析法测定口服给药后血清和唾液中乙炔雌二醇的浓度。通过唾液/血清商数，并根据唾液样本中乙炔雌二醇的浓度，可以推断出血清中乙炔雌二醇的含量。请注意商数与时间之间的关系，在计算数值时应予以考虑。口服给药后2小时、4小时和12小时，乙炔雌二醇剂量为0.05毫克时的唾液/血清商数分别为0.27、0.76和0.40。
