Frigeri L G, Khoo J C, Robel G
Horm Res. 1983;17(4):197-201. doi: 10.1159/000179698.
Although standard preparations of growth hormone activated hormone-sensitive lipase in differentiated 3T3-L1 adipocytes, more highly purified preparations of human and bovine hormones were not lipolytic in this system. We found that the standard preparations were contaminated with a lipolytic substance which was removed during purification of the growth hormone. The purified growth hormone likewise did not stimulate lipolysis in adipose tissue from fasted rats. Dexamethasone had no potentiating activity in either assay.
尽管生长激素的标准制剂能激活分化的3T3-L1脂肪细胞中的激素敏感性脂肪酶，但人源和牛源激素的更高纯度制剂在该系统中并无脂解作用。我们发现标准制剂被一种脂解物质污染，这种物质在生长激素纯化过程中被去除。纯化后的生长激素同样不能刺激禁食大鼠脂肪组织的脂解。地塞米松在两种检测中均无增强活性。
