血源淋巴细胞向异种红细胞刺激的大鼠腘淋巴结的迁移。
The migration of blood-borne lymphocytes into rat popliteal lymph nodes stimulated with xenogeneic red blood cells.
作者信息
Kimpton W G, Poskitt D C, Dandie G W, Muller H K
出版信息
Immunology. 1983 Sep;50(1):159-63.
The recruitment of radiolabelled blood-borne lymphocytes into rat popliteal lymph nodes (PLN) was investigated following the injection of varying doses of chicken (CRBC) or sheep red blood cells (SRBC) into the hind foot pad. Within the dose range tested (10(5)-10(8) RBC) an increase in the dose of injected antigen resulted in elevated levels of lymphocyte recruitment into the draining popliteal lymph node. The kinetics of lymphocyte recruitment with the same dose of CRBC or SRBC was similar even though these red cells differ in size and are antigenically non-cross-reactive. While little is known of the mechanisms which control the rate of entry of blood-borne lymphocytes into antigen-stimulated lymph nodes, the extent of lymphocyte recruitment was shown to be directly related to the quantity of antigen injected.
将不同剂量的鸡红细胞（CRBC）或绵羊红细胞（SRBC）注射到大鼠后足垫后，研究了放射性标记的血源淋巴细胞向大鼠腘窝淋巴结（PLN）的募集情况。在所测试的剂量范围内（10⁵ - 10⁸个红细胞），注射抗原剂量的增加导致引流腘窝淋巴结中淋巴细胞募集水平升高。即使这些红细胞大小不同且抗原性无交叉反应，但相同剂量的CRBC或SRBC引起的淋巴细胞募集动力学相似。虽然对控制血源淋巴细胞进入抗原刺激淋巴结速率的机制了解甚少，但淋巴细胞募集程度与注射抗原的量直接相关。
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