Effects of jambolan seed treatment on blood sugar, lipids and urea in streptozotocin induced diabetes in rabbits.

In New Zealand rabbits a single intravenous injection of streptozotocin (STZ 65 mg/kg) elevated the levels of blood sugar to 340 mg percent, which was associated with glycolysis, ureamia, hypercholesterolemia, hypertriglyceridemia and loss of body weight. Oral administration of jambolan seed (1 g/kg) in casein diet significantly lowered the elevated postmeal (1 1/2 hr after) values of blood sugar, cholesterol, FFA and triglyceride down to levels comparable to phenformin. Jambolan seed treatment failed to check ureamia. Weight loss was checked by phenformin and jambolan seed but the gain was not equivalent to that recorded in nondiabetic control. Like phenformin, jambolan seed too failed to control glycogenolysis in STZ-induced diabetes.