Pönkä A, Ojala K, Teppo A M, Weber T H
Infection. 1983 May-Jun;11(3):129-31. doi: 10.1007/BF01641290.
The lactate, lysozyme, C-reactive protein and serum amyloid-A protein concentrations in cerebrospinal fluid were measured in 11 patients with bacterial meningitis, 27 patients with aseptic meningitis and in 31 control patients. The mean concentration of each parameter was significantly higher (p less than or equal to 0.0001) in patients with bacterial meningitis than in those with aseptic meningitis or those without meningitis. The reliability of these tests in the differential diagnosis of bacterial and aseptic meningitis was compared with leucocyte counts in cerebrospinal fluid. Gram staining for bacteria, and protein and glucose levels. The cerebrospinal fluid lactate level proved to be more sensitive than lysozyme. C-reactive protein or serum amyloid-A protein and had a high degree of specificity.
对11例细菌性脑膜炎患者、27例无菌性脑膜炎患者及31例对照患者的脑脊液中的乳酸、溶菌酶、C反应蛋白和血清淀粉样蛋白A浓度进行了测定。细菌性脑膜炎患者各参数的平均浓度显著高于无菌性脑膜炎患者或无脑膜炎患者（p≤0.0001）。将这些检测方法在细菌性和无菌性脑膜炎鉴别诊断中的可靠性与脑脊液白细胞计数、细菌革兰染色以及蛋白和葡萄糖水平进行了比较。脑脊液乳酸水平被证明比溶菌酶、C反应蛋白或血清淀粉样蛋白A更敏感，且具有高度特异性。
