Rutledge J, Benjamin D, Hood L, Smith A
J Pediatr. 1981 Jan;98(1):20-4. doi: 10.1016/s0022-3476(81)80526-4.
The role of the cerebrospinal fluid lactate measurement was evaluated for the management of children with suspected bacterial meningitis. Although CSF lactate can be precisely measured, it provided no additional information over that which can be obtained from a CSF cell count. Reliance on the CSF lactate concentration alone would have increased the number of children being treated unnecessarily with antibiotics. There was neither clinical nor experimental evidence to suggest that the test should be used in the early diagnosis of meningitis. In patients with equivocal clinical and CSF findings, it failed to differentiate bacterial from nonbacterial infection. The data do not support the view that the measurement of CSF lactate has significant role in the management of children with suspected meningitis.
评估了脑脊液乳酸测定在疑似细菌性脑膜炎儿童管理中的作用。尽管脑脊液乳酸可以精确测量，但它并没有提供比脑脊液细胞计数更多的额外信息。仅依靠脑脊液乳酸浓度会增加不必要接受抗生素治疗的儿童数量。没有临床证据或实验证据表明该检测应用于脑膜炎的早期诊断。在临床和脑脊液检查结果不明确的患者中，它无法区分细菌感染和非细菌感染。这些数据不支持脑脊液乳酸测定在疑似脑膜炎儿童管理中具有重要作用这一观点。
