Stopp P E
Hear Res. 1983 Jul;11(1):55-72. doi: 10.1016/0378-5955(83)90045-x.
Guinea pigs, which were either anesthetized (A) or conscious (U), were exposed to four 2 h sessions of broad-band noise of 96 dB SPL. Cochlear microphonics and N1 thresholds were measured prior to killing from 1 to 13 days later. The cochleas were examined by SEM and by section. The U series suffered less N1 threshold loss and recovered within 10-13 days, while the large initial loss in the A series did not completely reverse within the period of study. Initially, the IHC stereocilia in the basal half of the cochlea showed marked bending, the affected area being somewhat more extensive in the A group. These hairs gradually recovered, although not progressively. On the other hand, the disturbance to OHC stereocilia, which appeared to be less pronounced early on and was more apically centered, developed over time into marked permanent damage. The outermost row consistently showed the greatest effect with hairs becoming elongated or fused, and occasionally lost altogether. Susceptibility to noise varied between individuals of both groups. The recovery of N1 threshold was concomitant with the recovery of the erectness of the IHC hairs.
将豚鼠分为麻醉组（A）和清醒组（U），使其暴露于4次、每次持续2小时、声压级为96分贝的宽带噪声中。在处死前1至13天测量耳蜗微音器电位和N1阈值。通过扫描电子显微镜（SEM）和切片检查耳蜗。U组的N1阈值损失较小，并在10至13天内恢复，而A组最初的较大损失在研究期间未完全逆转。最初，耳蜗基部一半的内毛细胞静纤毛出现明显弯曲，A组的受影响区域稍广。这些毛发逐渐恢复，尽管不是渐进式的。另一方面，外毛细胞静纤毛的干扰在早期似乎不太明显，且更集中于顶部，随着时间的推移发展为明显的永久性损伤。最外层的一排始终受影响最大，毛发变长或融合，偶尔完全消失。两组个体对噪声的易感性各不相同。N1阈值的恢复与内毛细胞毛发直立性的恢复同步。
