Woodman J L, Black J, Nunamaker D M
J Biomed Mater Res. 1983 Jul;17(4):655-68. doi: 10.1002/jbm.820170410.
An in vivo study of a new total finger joint prosthesis was performed to evaluate a biological ingrowth system of attachment of the device to bone. The prosthesis consisted of two conical ribbed ultrahigh molecular weight polyethylene plugs that were fixed by impaction into the medullary cavity after reaming. A cobalt--chromium alloy metal stemmed hinge slides inside the plugs with the joint articulation at the end of the stem. The focus of this study was to measure the concentration of cobalt and nickel in the serum, erythrocytes, and periarticular tissue (muscle from the sartorius and vastus medialis) resulting from the implantation of this device in the knee of the cat for periods of up to 1 year. The results indicate significant elevation in serum cobalt concentrations only after 5 months and increased concentrations in serum nickel which, were more pronounced after two months. Column chromatographic separations on cross-linked Dextran (G-200) shows a different distribution across the three principal protein peaks for each metal.
对一种新型全手指关节假体进行了一项体内研究，以评估该装置与骨骼附着的生物长入系统。该假体由两个锥形带肋超高分子量聚乙烯塞组成，在扩髓后通过压入固定在髓腔内。一个钴铬合金金属柄铰链在塞子内滑动，关节在柄的末端。本研究的重点是测量将该装置植入猫膝关节长达1年所导致的血清、红细胞和关节周围组织（缝匠肌和股内侧肌的肌肉）中钴和镍的浓度。结果表明，仅在5个月后血清钴浓度显著升高，血清镍浓度在两个月后升高更为明显。在交联葡聚糖（G - 200）上进行柱色谱分离显示，每种金属在三个主要蛋白质峰上的分布不同。
