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分泌抗神经胶质瘤单克隆抗体的杂交瘤中病毒颗粒的存在与缺失情况。

Presence and absence of virus particles in hybridomas secreting monoclonal antibodies against gliomas.

作者信息

Stavrou D, Bilzer T, Tsangaris T, Dürr E, Steinecke M, Anzil A P

出版信息

J Cancer Res Clin Oncol. 1983;106(1):77-80. doi: 10.1007/BF00399903.

DOI:10.1007/BF00399903
PMID:6885900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12252635/
Abstract

Hybridoma clones were produced by fusion of splenocytes from glioma-immunized hosts and the X63-Ag8.653 mouse myeloma line and Y3-Ag.1.2.3. rat myeloma line. Oncornavirus particles were found in all clones descending from the mouse myeloma line. No virus particles could be found in either the spleens of immunized Balb/c mice and Fischer rats or in the rat myeloma line and the hybridomas derived from it.

摘要

杂交瘤克隆是通过将来自胶质瘤免疫宿主的脾细胞与X63 - Ag8.653小鼠骨髓瘤细胞系以及Y3 - Ag.1.2.3大鼠骨髓瘤细胞系融合产生的。在源自小鼠骨髓瘤细胞系的所有克隆中均发现了肿瘤病毒颗粒。在免疫的Balb/c小鼠和Fischer大鼠的脾脏中，以及在大鼠骨髓瘤细胞系及其衍生的杂交瘤中均未发现病毒颗粒。

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本文引用的文献

1
The humoral antibody response of rats immunized with chemically modified syngeneic brain cells and glioma cells.用化学修饰的同基因脑细胞和胶质瘤细胞免疫的大鼠的体液抗体反应。
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Isolation and characterization of retrovirus-like elements from normal human fetuses.从正常人类胎儿中分离和鉴定类逆转录病毒元件
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The presence of viral particles in hybridoma clones secreting monoclonal antibodies.分泌单克隆抗体的杂交瘤克隆中病毒颗粒的存在。
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Monoclonal antibodies reactive with glioma cell lines derived from experimental brain tumors.与源自实验性脑肿瘤的胶质瘤细胞系发生反应的单克隆抗体。
Eur J Cancer Clin Oncol. 1983 Oct;19(10):1439-49. doi: 10.1016/0277-5379(93)90014-v.
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Viral particles in hybridoma clones secreting monoclonal antibodies.分泌单克隆抗体的杂交瘤克隆中的病毒颗粒。
Lancet. 1982 Aug 21;2(8295):445-6. doi: 10.1016/s0140-6736(82)90477-9.
6
Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG.大鼠×大鼠杂交骨髓瘤以及一种抗小鼠IgG Fd段的单克隆抗体。
Nature. 1979 Jan 11;277(5692):131-3. doi: 10.1038/277131a0.
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A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.一种新的小鼠骨髓瘤细胞系，该细胞系已丧失免疫球蛋白表达，但可用于构建分泌抗体的杂交细胞系。
J Immunol. 1979 Oct;123(4):1548-50.