Rasmussen D D, Ishizuka B, Quigley M E, Yen S S
J Clin Endocrinol Metab. 1983 Oct;57(4):760-3. doi: 10.1210/jcem-57-4-760.
The effect of oral tyrosine or tryptophan ingestion on plasma concentrations of norepinephrine (NE), dopamine (DA), epinephrine (EPI), and 3,4-dihydroxyphenylacetic acid (DOPAC) was investigated in a double blind, placebo-controlled study in fasted men. Tyrosine ingestion induced within 45 min a significant but short-lasting (approximately 30 min) increase in plasma concentrations of NE, EPI, and DA and a coincident decrease in plasma DOPAC levels. Ingestion of tryptophan or lactose placebo did not after plasma DA, EPI, NE, or DOPAC levels. Since plasma catecholamines derive from peripheral sources, while circulating DOPAC may reflect both brain and peripheral DA turnover, these results suggest that the oral ingestion of tyrosine can exert acute effects on catecholamine systems within and outside the brain.
在一项针对空腹男性的双盲、安慰剂对照研究中，研究了口服酪氨酸或色氨酸对去甲肾上腺素（NE）、多巴胺（DA）、肾上腺素（EPI）和3,4-二羟基苯乙酸（DOPAC）血浆浓度的影响。摄入酪氨酸后45分钟内，NE、EPI和DA的血浆浓度显著但短暂（约30分钟）升高，同时血浆DOPAC水平下降。摄入色氨酸或乳糖安慰剂后，血浆DA、EPI、NE或DOPAC水平没有变化。由于血浆儿茶酚胺来自外周来源，而循环中的DOPAC可能反映大脑和外周的DA周转率，这些结果表明口服酪氨酸可对脑内外的儿茶酚胺系统产生急性影响。
