Muytjens H L, Zanen H C, Sonderkamp H J, Kollée L A, Wachsmuth I K, Farmer J J
J Clin Microbiol. 1983 Jul;18(1):115-20. doi: 10.1128/jcm.18.1.115-120.1983.
Eight cases of neonatal meningitis due to Enterobacter sakazakii (formerly known as yellow-pigmented Enterobacter cloacae) which occurred in The Netherlands during the last 6 years were investigated retrospectively. Two patients had necrotizing enterocolitis and meningitis simultaneously. Despite treatment (in most cases with ampicillin and gentamicin), the fatality rate was 75%. Strains were much more susceptible to some of the new beta-lactam antibiotics than to ampicillin. A mode of transmission other than passage through the birth canal was likely, at least for some patients. A cluster of four patient strains in one hospital had almost identical plasmid DNA profiles. However, two strains isolated from formula at the same hospital 2 days after the onset of one case had different profiles, as did the strains from patients in other hospitals.
对过去6年在荷兰发生的8例由阪崎肠杆菌（以前称为产黄色色素的阴沟肠杆菌）引起的新生儿脑膜炎进行了回顾性调查。2例患者同时患有坏死性小肠结肠炎和脑膜炎。尽管进行了治疗（大多数情况下使用氨苄西林和庆大霉素），但死亡率仍为75%。这些菌株对某些新型β-内酰胺类抗生素比对氨苄西林更敏感。至少对一些患者来说，除了通过产道传播之外，可能还有其他传播方式。一家医院的4株患者菌株具有几乎相同的质粒DNA图谱。然而，在一例病例发病2天后从同一家医院的配方奶中分离出的两株菌株具有不同的图谱，其他医院患者的菌株也是如此。
