Smith W D, Jackson F, Jackson E, Williams J
J Comp Pathol. 1983 Jul;93(3):479-88. doi: 10.1016/0021-9975(83)90035-x.
Immunity to Ostertagia circumcincta was demonstrated in 5 previously infected sheep which were killed 10 days after challenge with 50 000 larvae. This immunity was expressed as a reduction in the number as well as the degree of development of the surviving parasites compared with those found in 6 control sheep. Gastric lymph was sampled from the immune group from 2 days before till 10 days after challenge and a secondary local immune response was detected. The main features of this response were a large increase in cell output in the lymph, especially in lymphoblasts and IgA-containing cells, which reached a peak on day 4 or 5, followed by a ten-fold increase in IgA immunoglobulin and IgA anti-worm antibody which reached a peak 7 or 8 days after challenge. The timing of these events suggested that the cellular, but not the IgA, response could have been involved in a putative mechanism which caused arrested development, although both components could have been implicated in mechanisms which may have caused expulsion of developing larvae.
在5只先前已感染的绵羊中证实了对环形奥斯特他线虫的免疫力，这些绵羊在接受50000条幼虫攻击后10天被宰杀。与6只对照绵羊相比，这种免疫力表现为存活寄生虫数量的减少以及发育程度的降低。从免疫组在攻击前2天直至攻击后10天采集胃淋巴液，检测到二次局部免疫反应。该反应的主要特征是淋巴液中细胞输出量大幅增加，尤其是成淋巴细胞和含IgA的细胞，在第4天或第5天达到峰值，随后IgA免疫球蛋白和IgA抗蠕虫抗体增加了10倍，在攻击后7或8天达到峰值。这些事件的时间表明，细胞反应而非IgA反应可能参与了导致发育停滞的假定机制，尽管这两个成分都可能参与了可能导致发育中幼虫排出的机制。
