Roy C C, Fournier L A, Chartrand L, Lepage G, Yousef I
J Pediatr Gastroenterol Nutr. 1983;2(1):152-8. doi: 10.1097/00005176-198302010-00018.
The hypothesis that the absence of pancreatic secretions from the lumen of the intestinal tract could alter the secretion rate of biliary lipids and the kinetics of bile salts was tested in rats with a pancreatic fistula fed intragastrically either a high or a low fat liquid diet over a 4-day period. In animals with external derivation of all pancreatic secretions who were given the high fat diet, stools were pale and bulky, the basal synthesis rate of bile acids was almost twice that of controls, and there was an increase in the secretion rate of cholesterol and phospholipids calculated from the first 2 h of bile collection. On the low fat diet, there was no change in basal bile salt synthesis, but the pool was larger and the secretion rate of bile acids and phospholipids was increased. A study of the quantitative relationship between the excretion rate of phospholipids and of cholesterol to that of bile acids following complete biliary diversion revealed a disproportionately large output of cholesterol at low bile acid flow rates under both diets in rats with a pancreatic fistula. These data suggest that experimental pancreatic insufficiency leads to alterations of the secretion rate of biliary lipids and to uncoupling of the close relationship between bile acids and cholesterol.
通过对患有胰瘘的大鼠进行为期4天的胃内喂养，分别给予高脂或低脂流质饮食，来验证肠道腔内缺乏胰腺分泌物是否会改变胆汁脂质分泌率和胆盐动力学这一假说。在所有胰腺分泌物都经外部引出且给予高脂饮食的动物中，粪便色浅且量大，胆汁酸的基础合成率几乎是对照组的两倍，并且根据最初2小时胆汁收集量计算得出的胆固醇和磷脂分泌率有所增加。在低脂饮食情况下，基础胆盐合成没有变化，但胆盐池更大，胆汁酸和磷脂的分泌率增加。对完全胆汁转流后磷脂、胆固醇排泄率与胆酸排泄率之间定量关系的研究表明，在两种饮食情况下，患有胰瘘的大鼠在低胆汁酸流速时胆固醇的排出量不成比例地大。这些数据表明，实验性胰腺功能不全导致胆汁脂质分泌率改变，并使胆酸与胆固醇之间的密切关系解偶联。
