Parsons H G, Beaudry P, Dumas A, Pencharz P B
J Pediatr Gastroenterol Nutr. 1983;2(1):44-9. doi: 10.1097/00005176-198302010-00005.
Children with cystic fibrosis (CF) frequently have growth retardation. Standard growth velocity is dependent on an adequate supply of energy. The effect of dietary counselling and high energy food supplementation on the growth of eight children (aged 4 to 9 years) with CF was determined. The 2-year study was divided into control and test periods each lasting 1 year. Only during the test period did the mean energy intake reach or exceed 100% of the recommended energy requirements. When energy intake increased, weight growth increased significantly (p less than 0.05). Even with pancreatic enzyme replacement, the CF subjects had increased fecal energy losses. Thus, since dietary energy intake would overestimate energy available for metabolism, absorbed energy was determined. There was a positive linear relationship between absorbed energy and weight gain (p less than 0.01). Normal rates of weight gain were seen once absorbed energy intakes reached 100-110% of requirements. The children grew in height and weight at normal rates during the test period, whereas they showed retarded growth during the control period. Our data provide evidence that children with CF have inadequate energy intakes. Furthermore, we have shown that absorbed energy intake is the principal factor limiting the growth of CF children in the age group studied. Finally, it is possible to promote normal growth in CF children with dietary counselling and high energy supplements.
患有囊性纤维化（CF）的儿童经常出现生长发育迟缓。标准生长速度取决于充足的能量供应。本研究测定了饮食咨询和高能量食物补充对8名4至9岁CF儿童生长的影响。这项为期2年的研究分为对照期和试验期，每期持续1年。仅在试验期，平均能量摄入量达到或超过推荐能量需求的100%。当能量摄入量增加时，体重增长显著增加（p<0.05）。即使使用了胰酶替代疗法，CF受试者的粪便能量损失仍有所增加。因此，由于饮食能量摄入量会高估可用于代谢的能量，所以测定了吸收的能量。吸收的能量与体重增加之间存在正线性关系（p<0.01）。一旦吸收的能量摄入量达到需求的100 - 110%，就会出现正常的体重增加率。在试验期，这些儿童的身高和体重以正常速度增长，而在对照期则出现生长发育迟缓。我们的数据表明，CF儿童的能量摄入不足。此外，我们已经表明，吸收的能量摄入量是限制所研究年龄组CF儿童生长的主要因素。最后，通过饮食咨询和高能量补充剂有可能促进CF儿童的正常生长。
