Campbell N C, Ekerot C F, Hesslow G
J Physiol. 1983 Jul;340:225-38. doi: 10.1113/jphysiol.1983.sp014760.
The plateau-like depolarizing potentials evoked in Purkinje cell dendrites by impulses in climbing fibres (Ekerot & Oscarsson, 1981) were conditioned by single parallel fibre volleys and investigated by intra- and extracellular recording from cat cerebellar cortex. The conditioning parallel fibre volleys evoked predominantly inhibitory potentials of long duration in the Purkinje cell dendrites. Massive parallel fibre volleys, which may evoke plateau-like depolarizing potentials (Campbell, Ekerot, Hesslow & Oscarsson, 1983) were avoided. In proximal dendrites parallel fibre volleys preceding climbing fibre responses reduced or abolished the plateau potential, whereas the initial spike-like component of the climbing fibre responses was largely unaffected. Parallel fibre stimulation during already established plateau potentials immediately terminated the plateaus. In distal dendrites parallel fibre stimulation preceding climbing fibre responses reduced or abolished both the plateau potential and the initial component of the climbing fibre responses. Parallel fibre stimulation during established plateau potentials did not immediately terminate the plateau potentials but reduced their duration. The results of the present investigation suggest that single dendritic branches of Purkinje cells serve as independent integrators of mossy fibre and climbing fibre inputs.
由攀缘纤维冲动在浦肯野细胞树突中诱发的平台样去极化电位（埃克罗特和奥斯卡松，1981年），由单个平行纤维群进行条件设定，并通过猫小脑皮质的细胞内和细胞外记录进行研究。条件性平行纤维群在浦肯野细胞树突中主要诱发长时间的抑制性电位。避免使用可能诱发平台样去极化电位的大量平行纤维群（坎贝尔、埃克罗特、赫斯洛和奥斯卡松，1983年）。在近端树突中，在攀缘纤维反应之前的平行纤维群会降低或消除平台电位，而攀缘纤维反应的初始峰样成分在很大程度上不受影响。在已经建立的平台电位期间进行平行纤维刺激会立即终止平台电位。在远端树突中，在攀缘纤维反应之前的平行纤维刺激会降低或消除平台电位以及攀缘纤维反应的初始成分。在已建立的平台电位期间进行平行纤维刺激不会立即终止平台电位，但会缩短其持续时间。本研究结果表明，浦肯野细胞的单个树突分支作为苔藓纤维和攀缘纤维输入的独立整合器。
