Campbell N C, Hesslow G
Neurosci Lett. 1984 Mar 23;45(2):187-92. doi: 10.1016/0304-3940(84)90097-1.
The present study investigated the duration of afterdepolarizations in Purkinje cell somata following climbing-fibre activation. Intracellular recordings revealed that, in cells with membrane potentials more negative than -50 mV and with normal spike-generating capabilities, climbing-fibre activation resulted in somatic responses with short afterdepolarizations. As the cell deteriorated and the resting membrane potential became more positive, the duration and form of the climbing-fibre response resembled the plateau potentials recorded from proximal dendrites. The absence of plateau potentials in undamaged Purkinje cell somata was confirmed by extracellular recording of test spike amplitudes following evoked climbing-fibre responses.
本研究调查了攀缘纤维激活后浦肯野细胞胞体中后去极化的持续时间。细胞内记录显示，在膜电位比-50mV更负且具有正常动作电位产生能力的细胞中，攀缘纤维激活导致胞体反应伴有短暂的后去极化。随着细胞功能恶化且静息膜电位变得更正，攀缘纤维反应的持续时间和形式类似于从近端树突记录到的平台电位。通过对诱发的攀缘纤维反应后测试动作电位幅度进行细胞外记录，证实了未受损浦肯野细胞胞体中不存在平台电位。
